| MONDAY, OCTOBER 22, 2018 | |
| 14:00-20:00 | Arrival and Registration (2nd floor, IGDB) |
| 17:30-19:00 | Dinner (2nd floor, IGDB) |
| 19:00-19:10 | Welcome and opening remarks |
| 19:10-20:00 |
Keynote lecture (Chaired by Caixia Gao) David R. Liu, Harvard University, USA Base editing: chemistry on a target nucleotide in the genome of living cells |
| 20:00-22:00 | Drinks (11th floor, coffee room) |
| TUESDAY, OCTOBER 23, 2018 | |
| Session 1: Genome Editing Technology and Tools-1 | |
| Session chair: Markus Elsner, Nature Biotechnology | |
| 9:00-9:30 | Jin-Soo Kim, Institute for Basic Science, South Korea Genome-wide target specificity of CRISPR RNA-guided base editors |
| 9:30-10:00 | Erik Sontheimer, University of Massachusetts Medical School, USA Enhancing genome editing with chemically modified guides and new Cas9 orthologs |
| 10:00-10:30 | Wei Li, Chinese Academy of Sciences, China Repurposing CRISPR-C2c1 for mammalian genome |
| 10:30-10:45 | Coffee break and poster session |
| Session 2: Genome Editing Technology and Tools-2 | |
| Session chair: David R. Liu, Harvard University, USA | |
| 10:45-11:15 |
Akihiko Kondo, Kobe University, Japan Genome editing with base editing systems from bacteria to plants |
| 11:15-11:45 | Jia Chen, ShanghaiTech University, China APOBEC: From mutator to editor |
| 11:45-12:00 | Shuqi Yan, Integrated DNA Technologies Inc, USA A comprehensive study comparing on- and off-target activity of the most common forms of CRISPR/Cas9 guide RNAs |
| 12:00-12:15 | Shannon M. Miller, Harvard University, USA Evolved Cas9 variants with broad PAM compatibility and high DNA specificity |
| 12:15-13:30 | Lunch and poster session |
| Session 3: Gene Regulation | |
| Session chair: Jin-Soo Kim, Institute for Basic Science, South Korea | |
| 13:30-14:00 | Patrick Hsu, Salk Institute, USA New molecular technologies for transcriptome engineering |
| 14:00-14:30 | Moritoshi Sato, The University of Tokyo, Japan Optical control of the genome |
| 14:30-15:00 | Lei Stanley Qi, Stanford University, USA Beyond editing: exploring and engineering a living genome using dead CRISPR molecule |
| 15:00-15:15 | Coffee break and poster session |
| 15:15-16:00 |
Keynote lecture George Church, Harvard Medical School, USA Beyond cutting |
| Session 4: Therapeutic Genome Editing | |
| Session chair: Dan Voytas, University of Minnesota, USA | |
| 16:00-16:30 |
Matthew Porteus, Stanford University, USA Genome editing of hematopoietic stem cells to cure genetic diseases |
| 16:30-17:00 |
Hao Yin, Wuhan University, China In vivo genome editing: from proof-of-concept to therapeutic delivery |
| 17:00-17:15 | Guanghui Liu, Chinese Academy of Sciences, China Using stem cell and gene editing techniques to study and treat aging-associated disorders |
| 17:15-18:00 | Meet-the-editor and poster session |
| 18:00-21:00 | Banquet |
| WEDNESDAY, OCTOBER 24, 2018 | |
| Session chair: Angela Key Eggleston, Nature | |
| 9:00-9:45 |
Keynote lecture Maria Jasin, Memorial Sloan Kettering Cancer Center, USA Protecting the genome by homologous recombination |
| Session 5: Genome Editing Technology and Tools-3 | |
| Session chair: Angela Key Eggleston, Nature | |
| 9:45-10:15 | Meng How Tan, Nanyang Technological University, Singapore Development and evaluation of novel tools for genome and transcriptome engineering |
| 10:15-10:30 | Qiang Wu, Shanghai Jiao Tong University, China Precise and predictable CRISPR chromosomal rearrangements reveal principles of Cas9-mediated nucleotide insertion |
| 10:30-10:45 | Coffee break and poster session |
| Session 6: Genome Editing Screens for Function and Disease Mechanisms | |
| Session chair: Maria Jasin, Memorial Sloan Kettering Cancer Center, USA | |
| 10:45-11:15 | Danwei Huangfu, Memorial Sloan Kettering Cancer Institute, USA Human development and disease through the lens of pluripotent stem cells |
| 11:15-11:45 | Wensheng Wei, Peking University, China Dissection of functional big data in biological contexts |
| 11:45-12:15 | Randall Platt, ETH Zurich, Switzerland In vivo gene editing and genetic screening with CRISPR-Cas systems |
| 12:15-13:30 | Lunch and poster session |
| Session 7: Molecular Mechanism of CRISPR | |
| Session chair: Wensheng Wei, Peking University, China | |
| 13:30-14:00 | Yanli Wang, Chinese Academy of Sciences, China CRISPR-Cas mediated cleavage of invading nucleic acids |
| 14:00-14:30 | Osamu Nureki, The University of Tokyo, Japan Molecular mechanism of CRISPR and structure-based development of genome editing tool towards medical applications |
| 14:30-15:00 | Hyongbum Henry Kim, Yonsei University, South Korea Highly accurate prediction of CRISPR-Cpf1 activity at endogenous target sites |
| 15:00-15:15 | Coffee break and poster session |
| Session 8: Animal and Plant Biotechnology | |
| Session chair: Susan Jones, Nature Biotechnology | |
| 15:15-15:45 | Weizhi Ji, Kunming University of Science and Technology, China Gene editing in monkey |
| 15:45-16:15 | Caixia Gao, Chinese Academy of Sciences, China Fine-tuning protein translation level by genome editing |
| 16:15-16:45 | Dan Voytas, University of Minnesota, USA Expression of developmental regulators for accelerated plant gene editing |
| 16:45-17:15 | Liangxue Lai, Chinese Academy of Sciences, China Generation of gene editing pig model for human Huntington's disease |
| 17:15-17:30 | Karen Massel, The University of Queensland, Australia CRISPR/Cas9 knock-out of a major grain storage protein gene in Sorghum bicolor leads to improved grain quality |
| 17:30-18:30 | Meet-the-editor and poster session |
| 18:30-19:30 |
Dinner (2nd floor, IGDB) |
The State Key Laboratory of Plant Cell and Chromosome Engineering
National Natural Science Foundation of China
Chinese Academy of Sciences
Institute of Genetics and Developmental Biology, CAS